Application of mesenchymal stem cells in joint diseases
نویسندگان
چکیده
Abstract Introduction Multilineage differential potentials and immunomodulatory function of mesenchymal stem cells have led to the birth of subfield of regenerative medicine. More than a thousand clinical trials have been conducted, including clinical trials treating joint diseases, e.g. osteoarthritis and inflammatory arthritis. This review is to summarize preclinical studies of mesenchymal stem cells or mesenchymal stem cells-like cells in arthritis, with a focus on currently unsolved issues in utilising the regenerative and immunomodulatory properties of mesenchymal stem cells. Conclusion Numerous issues remain in utilising mesenchymal stem cells in treating joint diseases. Quantitative measurement of chondrogenic capacity, demonstration of long-term survival and engraftment after transplantation, further understanding the mechanism of immunomodulatory function are pivotal for the application of mesenchymal stem cells in treating joint diseases.
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